| # | Name | Origin | Meaning | Gender | |
|---|---|---|---|---|---|
| 441 | Sancho | Spanish | Saint. | M | |
| 442 | Santiago | Spanish | Named for Saint James. | M | |
| 443 | Santos | Spanish | Saint. | M | |
| 444 | Saturnin | Spanish | Gift of Saturn. | M | |
| 445 | Saul | Spanish | Asked for. | M | |
| 446 | Sebastiano | Spanish | Spanish form of Sebastian 'revered'. | M | |
| 447 | Segundo | Spanish | Born second. | M | |
| 448 | Sein | Spanish | Innocent. | M | |
| 449 | Senon | Spanish | Lively. | M | |
| 450 | Serafin | Spanish | Seraph. | M | |
| 451 | Severo | Spanish | Strict; restrained. | M | |
| 452 | Silverio | Spanish | Variant of Sylvanus referring to the mythological Greek god of trees. | M | |
| 453 | Silvino | Spanish | Variant of Sylvanus referring to the mythological Greek god of trees. | M | |
| 454 | Stefano | Spanish | Crown of laurels. | M | |
| 455 | Tabor | Spanish | Plays a small drum. | M | |
| 456 | Tadeo | Spanish | Praise. | M | |
| 457 | Tajo | Spanish | Day. | M | |
| 458 | Taurino | Spanish | Bull-like. The constellation Taurus. | M | |
| 459 | Tauro | Spanish | Bull-like. The constellation Taurus. | M | |
| 460 | Tavio | Spanish | Abbreviation of Octavio 'eighth.'. | M | |