| # | Name | Origin | Meaning | Gender | |
|---|---|---|---|---|---|
| 421 | Eduardo | Spanish | Prosperous guardian. | M | |
| 422 | Edwardo | Spanish | Prosperous guardian. | M | |
| 423 | Efrain | Spanish | Doubly fruitful. Form of Hebrew Ephraim. | M | |
| 424 | Elbertina | Spanish | Noble. | F | |
| 425 | Eldora | Spanish | Blond or gift of the sun. A name given to many saints. | F | |
| 426 | Eleadora | Spanish | Gift of the sun. A name given to many saints. | F | |
| 427 | Eleanora | Spanish | Shining light, or bright one. A variant of the Greek Helen. | F | |
| 428 | Eleena | Spanish | Shining light, or bright one. A variant of the Greek Helen. | F | |
| 429 | Elena | Spanish | Shining light, or bright one. A variant of the Greek Helen. | F | |
| 430 | Elia | Spanish | My God is Jehovah. Variant of Hebrew Elijah. | M | |
| 431 | Elias | Spanish | My God is Jehovah. Variant of Hebrew Elijah. | M | |
| 432 | Eliazar | Spanish | God has helped. | M | |
| 433 | Elija | Spanish | My God is Jehovah. Variant of Hebrew Elijah. | M | |
| 434 | Elina | Spanish | Shining light, or bright one. A variant of the Greek Helen. | F | |
| 435 | Elisa | Spanish | Spanish form of Elizabeth: consecrated to God. | F | |
| 436 | Eloisa | Spanish | Variant of Louise. See also Heloise. | F | |
| 437 | Eloy | Spanish | Renowned warrior. | M | |
| 438 | Elsa | Spanish | Truth. | F | |
| 439 | Elvera | Spanish | Truth. | F | |
| 440 | Elvio | Spanish | Blond. | M | |