| # | Name | Origin | Meaning | Gender | |
|---|---|---|---|---|---|
| 441 | Sempronius | Shakespearean | 'The Life of Timon of Athens' 'The Tragedy of Titus Andronicus' Kinsman to Titus. | M | |
| 442 | Servilius | Shakespearean | 'The Life of Timon of Athens' | M | |
| 443 | Sextus | Shakespearean | Antony and Cleopatra'. Sextus Pompeius, Roman triumvir. | M | |
| 444 | Seyton | Shakespearean | 'The Tragedy of Macbeth' Attendant to Macbeth. | M | |
| 445 | Shadow | Shakespearean | 'King Henry IV, Part 2' Simon Shadow, a country soldier. | M | |
| 446 | Shallow | Shakespearean | 'King Henry IV, Part 2' and 'The Merry Wives of Windsor' Robert Shallow, a country justice. | M | |
| 447 | Shepherd | Shakespearean | 'The Winter's Tale' The reputed father of Perdita is an old shepherd in the play. | M | |
| 448 | Shrewsbury | Shakespearean | 'Henry VI, Part 1' Lord Talbot, afterwards Earl of Shrewsbury. | M | |
| 449 | Shylock | Shakespearean | 'The Merchant of Venice' A rich Jew who loans money to Antonio. | M | |
| 450 | Sicinius | Shakespearean | 'The Tragedy of Coriolanus.' Sicinius Velutus, Tribune of the People. | M | |
| 451 | Silence | Shakespearean | 'King Henry IV, Part 2' A country justice. | M | |
| 452 | Silius | Shakespearean | Antony and Cleopatra'. An officer in Ventidius's army. | M | |
| 453 | Silvius | Shakespearean | As You Like It' A shepherd. | M | |
| 454 | Simon | Shakespearean | 'King Henry IV, Part 2' Simon Shadow, a country soldier. | M | |
| 455 | Simonides | Shakespearean | 'Pericles, Prince of Tyre' Simonides, King of Pentapolis. | M | |
| 456 | Simpcox | Shakespearean | 'Henry VI, Part 2' Saunder Simpcox, an impostor. | M | |
| 457 | Simple | Shakespearean | 'The Merry Wives of Windsor' Servant to Slender. | M | |
| 458 | Siward | Shakespearean | 'The Tragedy of Macbeth' Siward, Earl of Northumberland, general of the English forces. Also Young Siward, his son. | M | |
| 459 | Slender | Shakespearean | 'The Merry Wives of Windsor' Cousin to Shallow. | M | |
| 460 | Sly | Shakespearean | 'King Richard III' Christopher Urswick, a priest. 'The Taming of the Shrew' Christopher Sly, a tinker. | M | |