| # | Name | Origin | Meaning | Gender | |
|---|---|---|---|---|---|
| 2201 | Sibyl | Greek | Prophetess; oracle. | F | |
| 2202 | Sibylla | Greek | Prophetess; oracle. | F | |
| 2203 | Sidney | Greek | From Sidon. | M | |
| 2204 | Sidony | Greek | Linen. Shroud of Christ. | F | |
| 2205 | Sim | Greek | Diminutive of Simon: Snub-nosed. | M | |
| 2206 | Simeon | Greek | Sign. | M | |
| 2207 | Simon | Greek | Snub-nosed. Can also be a variant of a Hebrew name meaning 'hear; listen.' In the bible Simon was the name of two apostles including Simon Peter. | M | |
| 2208 | Simona | Greek | Feminine form of Simon: Snub-nosed. | F | |
| 2209 | Simone | Greek | Feminine form of Simon: Snub-nosed. | F | |
| 2210 | Sinobia | Greek | Stranger. | F | |
| 2211 | Sinon | Greek | Convinced the Trojans to pull the horse inside the city walls. | M | |
| 2212 | Sinovia | Greek | Stranger. | F | |
| 2213 | Sirena | Greek | Named for the Sirens. | F | |
| 2214 | Sirina | Greek | Named for the Sirens. | F | |
| 2215 | Sisyphus | Greek | Son of Aelous. | M | |
| 2216 | Socrates | Greek | Name of a philosopher. | M | |
| 2217 | Sofi | Greek | Wise. | F | |
| 2218 | Sofia | Greek | Wise. | F | |
| 2219 | Sofronia | Greek | Wise. | F | |
| 2220 | Solon | Greek | Wise. | F | |